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KMID : 0363320000210020243
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 2 p.243 ~ p.250
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Experimental Effect of Yukmi-Jihwang-Tang on the T-lymphocytes and Macrophages
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Jeon Jin-Oh
Jung Hyun-Woo
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Abstract
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Objectives : Yukmi-Jihwang-Tang(YJT) has been used in Oriental Medicine as a drug for tonifying and nourishing yin. So, the purpose of this Study was to investigate effects of Yukmi-Jihwang-Tang extract(YJTE) on the T-lymphocytes and peritoneal macrophages in mice.
Methods : YJTE consists of the following components; Rehmaniae Radix Preparata(熟地黃), Dioscoreae Rhizoma(山藥), Corni-Fructus(山茱萸), Hoelen alba(白茯), Moutan Cortex Radicis(牧丹皮), Alismatis Rhizoma(澤瀉).
Result : The results of this Study were obtained as follow; The administration of YJTE did not affect T-lymphocytes apoptosis. YJTE decreased sub-population of TH and TC cells, and proliferation of T-lymphocytes too. But YJTE accelerated phagocytic activity and Nitric Oxide(NO) production from peritoneal macrophages in mice.
Conclusions : These results suggest that the administeration of YJTE suppresses T-cell mediated immunity, but activates peritoneal macrophages
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KEYWORD
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Yukmi-Jihwang-Tang, T-lymphocytes, apoptosis, sub-population, phagocytic activity, Nitric Oxide(NO)
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